While many questions remain about the President’s condition and when he was first diagnosed with the coronavirus that causes Covid-19, here is what has been revealed so far about what he was been treated with — and when.
On Friday afternoon, the White House said in a letter that President Donald Trump was treated with an 8-gram dose of the experimental antibody therapy cocktail made by the biotechnology company Regeneron.
To make its monoclonal antibody therapy, Regeneron scientists selected two antibodies that best neutralized a version of the novel coronavirus in the lab. Antibodies are proteins the body makes to fight infection. The scientists copied those two antibodies to make a treatment for Covid-19.
The greatest improvements were seen in patients who had not mounted a natural response to the coronavirus infection.
The treatment also seemed to reduce the need for medical visits for the patients, none of whom were sick enough to be hospitalized at the start of this trial, according to Regeneron.
More patient data will need to be analyzed to know for sure how well the treatment works.
Regeneron’s therapy is not approved for any use and has not received emergency use authorization from the US Food and Drug Administration — but Regeneron is in talks with regulators to see if the FDA would consider an EUA.
The New York-based company confirmed that it provided the drug under a “compassionate use” request from the President’s physicians, but did not specify when it received the request. “There is limited product available for compassionate use requests that have been approved under rare, exceptional circumstances on a case-by-case basis,” Regeneron said in a statement released Friday. These requests must be initiated by a physician.
Some may be able to receive the treatment as part of a clinical trial, where they might receive the therapy or a placebo, or dummy treatment.
President Trump is being given a five-day course of the antiviral drug remdesivir, one of the doctors treating him said during a briefing on Saturday. The treatment is intended to shorten recovery time for Covid-19 patients.
“Yesterday evening he received his first dose of IV remdesivir and our plan is to continue a five-day treatment course for remdesivir,” Dr. Brian Garibaldi, one of the team of doctors treating Trump at the Walter Reed National Military Medical Center, told reporters on Saturday.
The trial included nearly 600 patients randomly assigned to receive either the current standard of care for Covid-19; a five-day course of remdesivir in addition to the current standard of care; or 10 days of the drug plus care. The recovery of each patient was tracked and examined.
The study found patients with moderate Covid-19 who received a five-day course of remdesivir were more likely to get better after 11 days compared to those who received standard care alone.
President Trump was given the corticosteroid drug dexamethasone on Saturday after his oxygen level transiently dipped, White House physician Dr. Sean Conley said during a briefing on Sunday.
“We decided that in this case the potential benefits early on in the course probably outweighed the risks,” Conley said.
Dr. Rochelle Walensky, chief of infectious diseases at Massachusetts General Hospital, said the use of dexamethasone for Trump’s care had some “scratching our heads.”
“Generally you start the dexamethasone when you’re starting to worry that they’re heading down the wrong path,” Walenksy said. “So, what happened today? Either he progressed or people are like, well, let’s just throw the kitchen sink at him.
“It’s unclear to me why they would have given him that if he did not require supplemental oxygen.”
The drug is typically given to patients on supplemental oxygen or needing ventilation.
That trial included about 6,400 hospitalized Covid-19 patients, a third of whom who were randomized to receive dexamethasone, and the rest given the usual standard of care at their hospitals.
In the early trial, dexamethasone was provided at a dose of 6 mg once a day for up to 10 days, either as an injection or orally. The researchers reported no serious adverse events among the patients taking dexamethasone.
“The Panel recommends against using dexamethasone for the treatment of Covid-19 in patients who do not require supplemental oxygen,” the NIH guidelines read.
In the study on dexamethasone, about 23% of patients who got dexamethasone died, compared to about 26% of those who did not.
“No survival benefit was seen among participants who did not require oxygen therapy at enrollment,” the NIH said. There’s a reason for this — the drug reduces inflammation, but in doing so, can impair the body’s ability to fight off infection.
Steroids are widely available and already commonly used to treat seriously ill Covid-19 patients.
Late Friday morning, “the President had a high fever and his oxygen saturation was transiently dipping below 94%,” Conley said. A normal blood oxygen saturation level is 95% or higher.
The President initially was “fairly adamant that he didn’t need” oxygen. “He was not short of breath. He was tired, had the fever, and that was about it,” Conley said.
However, the President was given oxygen.
“And after about a minute on only two liters, his saturation levels were back over 95%. He stayed on that for about an hour maybe, and was off and gone,” Conley said.
The NIH notes that hypoxemia, or a low level of oxygen in the blood, is common in Covid-19 patients.
Zinc, vitamin D, famotidine, melatonin and daily aspirin
On Friday afternoon, Conley said in a White House letter that Trump also has taken zinc, vitamin D, the heartburn drug famotidine, melatonin and a daily aspirin.
Zinc is a nutrient naturally found in the body that helps the immune system fight off outside bacteria and viruses — but while zinc supplements are often taken to reduce the length of colds, there is no evidence that they can be used to treat Covid-19.
Taking too much vitamin D can lead to a toxic buildup of calcium in the blood, causing confusion, disorientation and problems with heart rhythm, as well as bone pain, kidney damage and painful kidney stones.
The White House letter also noted that the President has been taking famotidine, commonly used to treat ulcers, heartburn and indigestion by reducing the amount of acid in the stomach.
Ten Covid-19 patients who were taking the drug while treating their illness at home may have found relief, according to a study published in June in the medical journal Gut. Famotidine is the active ingredient in Pepcid AC.
A coauthor of the study emphasized that it was in a small group of patients.
More research is needed to determine the efficacy of famotidine as a potential Covid-19 treatment.
Melatonin was also given to the President and more research is needed to determine its potential benefits for Covid-19 patients, but some studies suggest it could help Covid-19 patients who also have diabetes and obesity.
“A common trend exists between the increased number of SARS-COV-2-infected cases and the low levels of blood melatonin in people with chronic metabolic diseases and elderly people,” the researchers, from Mansoura University in Egypt wrote in the paper.
“The ability of melatonin to decrease viral infections in obese and diabetic patients is attributed to its characteristics such as potent antioxidant effects, improving the endogenous antioxidant system, immunomodulatory, and the strong anti-inflammatory capability,” the researchers wrote.
It’s not clear what dose of aspirin Trump was taking and whether he had already been taking it. Many people are prescribed low-dose aspirin for heart health.