Home > Health > Textured Implants Linked to Increased Breast Cancer Recurrence Risk

Textured Implants Linked to Increased Breast Cancer Recurrence Risk

16 Views
Textured Implants Linked to Increased Breast Cancer Recurrence Risk 2

NEW YORK (Reuters Health) – Using textured implants for reconstruction after mastectomy is associated with greater risk of breast cancer recurrence compared to smooth implants, according to new findings in JAMA Surgery.

“We initiated this study for the purpose of obtaining evidence that implant surface type is not significantly associated with breast cancer prognosis in an effort to relieve the vague anxiety of patients with breast cancer,” Dr. Sa Ik Bang of Samsung Medical Center at Sungkyunkwan University School of Medicine in Seoul, South Korea, and colleagues note.

They add, “Contrary to expectations, we found that the textured implant group had a significantly worse DFS than the smooth group, and this difference remained significant after adjusting for tumor stage and ER status.”

Textured implants are intended to reduce capsular contracture and implant malrotation. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) was first reported in the late 1990s, Dr. Bang and colleagues note, and textured implants have been proposed as a risk factor. Biofilm may be more likely to form on the textured surface, the authors suggest, leading to chronic inflammation in the surrounding tissue.

They looked at 650 patients, representing 687 cases, who underwent total mastectomy and immediate reconstruction at their hospital in 2011-2016. All were followed for at least two years after implant insertion. About 40% of cases received smooth implants and 60% textured implants. The smooth and textured groups had similar distribution of tumor stage and similar rates of adjuvant radiotherapy and chemotherapy. Five-year local and regional recurrence-free survival and disease-free survival (DFS) were 96.7% and 95.2%, respectively.

DFS was significantly lower with textured implant use after adjustment for tumor stage and estrogen receptor (ER) status (hazard ratio 3.054). The association was similar for patients with ER-positive cancer (HR 3.13) and patients with invasive cancer (HR 3.044). The association was especially pronounced in patients with stage II or II disease (HR 8.874). Implant surface texture was not associated with local and regional recurrence-free survival.

The authors suggest that textured implants may cause systemic inflammation, contributing to breast cancer recurrence.

“We believe that this study raises an urgent need for further well-designed investigations, which either may refute the findings of this study with more solid evidence and reassure patients or may produce similar results and lead to increased caution in breast cancer surveillance,” they conclude.

In an editorial, Dr. Michael R. Cassidy and Dr. Daniel S. Roh of Boston University write: “Given the association of textured implants with ALCL, and now the suggestion that they are associated with increased risk for breast cancer recurrence, surgeons who choose textured implants should counsel their patients with breast cancer about their possible consequences. Many reconstructive surgeons across the world have already abandoned the use of textured implants altogether.”

Dr. Bang was not available for an interview by press time.

SOURCE: https://bit.ly/3dkdQbI and https://bit.ly/3jUcp6v JAMA Surgery, online October 7, 2020.

Source link

TAGS , , , , , , , , , ,
Hi guys, this is Kimmy, I started LicensetoBlog to help you with the latest updated news about the world with daily updates from all leading news sources. Beside, I love to write about several niches like health, business, finance, travel, automation, parenting and about other useful topics to keep you find the the original information on any particular topic. Hope you will find LicensetoBlog helpful in various ways. Keep blogging and help us grow as a community for internet lovers.