Tag: toxicology

Tool Predicts Severe Toxicity From Chemo in Breast Cancer

A new tool for predicting the risk of severe chemotherapy toxicity in older adults with early-stage breast cancer outperforms existing models and should help older...

First CAR T-cell Tx for Mantle Cell Lymphoma Fills Unmet Need

The US Food and Drug Administration (FDA) granted accelerated approval on July 24, 2020, for the chimeric antigen receptor (CAR) T-cell therapy brexucabtagene autoleucel (Tecartus)...

Doctors Underreport Side Effects of Breast Irradiation

There is a substantial mismatch between patient and physician reports of toxicity during radiotherapy for breast cancer, according to an analysis of nearly 10,000 U.S....

Long-term APBI Cosmetic, Toxicity Data Reported

Long-term cosmetic and toxicity outcomes are good for both accelerated partial breast irradiation (APBI) delivered with 3D-conformal radiotherapy and whole-breast irradiation (WBI), with the latter...

Durable Responses With Anti-BCMA CAR T-cell for Multiple Myeloma

For patients with heavily-pretreated multiple myeloma, the early and deep responses seen with the novel chimeric antigen receptor T-cell (CAR T-cell) construct ciltacabtagene autoleucel (cilta-cel)...

Fracking Sites Tied to Increased Heart Failure Hospitalizations

Living near hydraulic fracturing is associated with increased risk of hospitalization in people with heart failure (HF), a new study from Pennsylvania suggests. The link...

From Cradle to Grave, Alcohol Is Bad for the Brain

There is “compelling” evidence of the harmful effects of alcohol on the brain. The greatest risk occurs during three periods of life that are marked...

Hand Sanitizer Poisonings Soar, Psych Patients at Risk

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Cases of poisoning — intentional and unintentional — from ingestion of...

Slow Taper off Antimalarial Avoids Lupus Flare During Remission

Slowly tapering off – or remaining on – antimalarial medications can help prevent disease flare in patients with systemic lupus erythematosus (SLE) who’ve achieved clinical...

Two-Drug Combo Standard of Care in Advanced Endometrial Cancer

Carboplatin plus paclitaxel (TC) should be the global first-line standard treatment for advanced endometrial cancer, new findings suggest. The combination proved to be noninferior to...

Collagen Crosslinking Shows Promise for Keratitis

Corneal collagen crosslinking, a procedure developed for keratoconus, could treat keratitis as effectively as antimicrobials, a new study suggests. The procedure could prove particularly useful...

Biometric Changes on Fitness Trackers Detect COVID-19

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. A smartphone app that combines passively collected physiologic data from wearable...

3 Factors Predict Cardiac Events in Overdose Patients

A predictive rule that can help triage drug overdose patients for the risk for cardiac arrest, shock, ventricular dysrhythmias, or myocardial injury has been validated...

A Guide to the New Agents Reshaping Ovarian Cancer Treatment

The treatment of ovarian cancer has evolved considerably in the last few years, with the approval of several PARP inhibitors, antiangiogenic agents, and other therapies...

‘Impressive’ Outcomes Sans Chemo in Poor-Prognosis ALL

The days of using chemotherapy to treat Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) may be numbered. In a phase 2 trial, up-front chemo-free induction/consolidation...

Conservative Parameters’ Key to Maximizing Cosmetic Results

Cosmetic laser procedures in darker skin types are associated with higher risks of pigmentary alterations and scarring, but can be performed safely with special considerations,...

Tough to Tell COVID From Smoke Inhalation Symptoms

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. The patients walk into Dr. Melissa Marshall’s community clinics in Northern...

Seeping Under Doors, Bad Air From West’s Fires Won’t Ease Up

PORTLAND, Ore. (AP) — Dangerously dirty air spewing from the West Coast wildfires is seeping into homes and businesses, sneaking into cars through air conditioning...

Kids Missing Critical Windows for Lead Testing Due to Pandemic

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. CLEVELAND — Families skipping or delaying pediatric appointments for their young...

Hazardous Air Pollutants Make COVID-19 More Serious

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. This article was produced in partnership with The Times-Picayune and The...

App for MS Aims to Capture Elusive Signals of Progression

Investigators in Switzerland are testing an application for smartphones that they hope will elucidate subtle signs of disease progression in multiple sclerosis (MS)—beyond what standard...

Multivalent Prodrug Tames Camptothecin Resistance in Solid Tumors

NEW YORK (Reuters Health) – Incorporating camptothecins into a multivalent, polymer-based prodrug can overcome resistance in high-risk solid tumors and reduce toxicities, researchers found in...

Holographic Display Aims to Improve Accuracy in Cardiac Ablation

Use of a real-time holographic mixed-reality display can significantly improve the electrophysiologist’s point navigation and accuracy during cardiac ablation, according to the first-in-human experience with...

Merkel Tells Russia to Investigate Suspected Poisoning of Navalny

BERLIN (Reuters) – German Chancellor Angela Merkel on Monday called on Russia to investigate the suspected poisoning of Russian opposition figure Alexei Navalny and hold...

Smartphone App May Help Detect Diabetes

A smartphone app (Azumio Instant Heart Rate) may be a non-invasive method for identifying individuals with diabetes by detecting a “digital biomarker” of vascular changes,...