Tag: tolerance

Pregnancy Safe After Transposition of the Great Arteries Surgery

NEW YORK (Reuters Health) – Women who have had the arterial switch operation to correct transposition of the great arteries tolerate pregnancy well with few...

FDA Toughens REMS Requirements for Some Fentanyl Products

Concern about potentially inappropriate prescribing of transmucosal immediate-release fentanyl (TIRF) products has prompted the US Food and Drug Administration (FDA) to toughen requirements in the...

Digoxin a ‘Viable Alternative’ in AF With HF: RATE-AF Published

A randomized trial shows no significant difference in the primary endpoint of quality of life at 6 months between treatment with digoxin vs the beta-blocker...

Adding Atezolizumab to Chemo Doesn’t Worsen QOL in Early TNBC

Adding the immune checkpoint inhibitor atezolizumab to first-line therapy for early triple-negative breast cancer (TNBC) did not significantly worsen patients’ quality of life, according to...

Interim Data Show 94.5% Efficacy for Its COVID-19 Vaccine

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. The Moderna mRNA-1273 vaccine, in development to prevent COVID-19, yielded 94.5%...

Topical Tapinarof Effective in Pivotal Psoriasis Trials

Tapinarof cream 1% applied once daily in patients with plaque psoriasis convincingly hit its primary and secondary endpoints and was well tolerated in two identical...

Lead-in or No, Switch to Long-Acting Monthly ART Is Safe

Individuals who have virologic suppression of HIV with daily oral dolutegravir/abacavir/lamivudine (DTG/ABC/3TC) can be switched safely with or without an oral lead-in phase to monthly injectable...

‘Overwhelming Evidence’ FDA’s Opioid Approval Process Is Shoddy

Despite the ongoing epidemic of misuse, overuse, and diversion of opioids, the US Food and Drug Administration (FDA) has set a low bar for approval...

Evolocumab Safe and Effective in Pediatric FH

The PCSK9 monoclonal antibody evolocumab (Repatha, Repatha Repatha Amgen) was well tolerated and effectively lowered LDL cholesterol by 38% compared with placebo in a randomized controlled...

Novel Oral Drug Improves Sunlight Tolerance

Dersimelagon, a novel once-daily oral selective melanocortin-1 receptor agonist, significantly boosted sunlight tolerance in patients with erythropoietic protoporphyria in a multicenter, phase 2, randomized trial,...

Set Up Your Hyperhidrosis Patients for Treatment Success

When children and adolescents first present to George Hightower, MD, PhD, with suspected primary hyperhidrosis, he tries to gauge their level of impairment and distress....

New Insight into Neurobehavioral Effects of Legalized Cannabis

Researchers have published one of the first studies to characterize the association between the consumption of legal cannabis and subsequent pharmacologic and neurobehavioral outcomes, with...