Tag: meta-analysis

Early BP Variability After ICH Predicts Disability

Greater short-term variability in systolic blood pressure after intracerebral hemorrhage (ICH) is associated with an increased risk for long-term disability, new research suggests. A pooled...

Aspirin Boosts Polypill Primary Prevention, Claims Meta-Analysis

The “polypill concept” of fixed-dose combinations of inexpensive generic cardiovascular (CV) drugs, whether or not in a single pill, is perhaps most controversial in the...

‘No Reason to Drop tPA’ in Stroke Thrombectomy: SWIFT DIRECT

A new study has failed to show noninferiority of direct thrombectomy compared to bridging therapy with thrombolysis before thrombectomy for patients with large-vessel occlusion ischemic...

Influenza Antivirals Perform Similarly Compared With Placebo

Although four different antiviral drugs for influenza successfully reduced the time it took to relieve symptoms, zanamivir outperformed the others by alleviating symptoms fastest, according...

Journal Takes 3 Years to Act

  More than three and a half years after being alerted to concerns about the data in a 2015 article, an obstetrics journal has finally...

Most Orthopedic Joint Surgery Lacks Scientific Justification

A meta-analysis of the 10 most common orthopedic procedures shows that most lack firm scientific support, according to British researchers. In some cases, they are...

Heartburn Drugs Improve Blood Sugar Control in Diabetes

WASHINGTON—Antacids improved blood sugar control in people with diabetes but had no effect on reducing the risk of diabetes in the general population, according to...

Time-Restricted Eating Is ‘Promising, But More Data Are Needed’

Time-restricted eating — that is, reducing the number of hours a person is allowed to eat during the day — may produce a modest 1%...

Noted Ability of Mozart’s Music to Reduce Seizures Explained?

Listening to Mozart has a notable impact on seizure reduction in patients with epilepsy —  and now researchers believe they know why, new research suggests....

Meta-analysis Muses Over ISCHEMIA Message Had Trial Lasted Longer

Would the ISCHEMIA trial be quite the compass for conservative care it now is in stable coronary artery disease (CAD) if follow-up for the primary...

Stethoscope, Doppler May Outperform Newer Fetal Monitoring Tools

For intrapartum fetal surveillance, the old way may be the best way, according to a meta-analysis involving more than 118,000 patients. Intermittent auscultation with a...

Eating More Fat May Boost Borderline Low Testosterone

“Low-fat diets appear to decrease testosterone levels in men, but further randomized controlled trials are needed to confirm this effect,” the authors of a meta-analysis...

Declining Sperm Count Tied to Chemicals in the Environment

Chemicals that pervade our modern world — plastics, pesticides, stain repellents, components of personal hygiene products — are contributing to a decades-long decline in fertility...

Outcomes Have Improved for PAH in Connective Tissue Disease

Survival rates for patients with pulmonary arterial hypertension associated with connective tissue diseases have improved significantly in recent years, and there is growing evidence that...

FDA Expands Sacubitril/Valsartan Indication to Embrace Some HFpEF

The US Food and Drug Administration (FDA) has approved a groundbreaking expanded indication for sacubitril/valsartan (Entresto), making it the first drug in the United States...

Low-Dose Aspirin Did Not Reduce Preterm Birth Rates

Women at risk of preterm birth who took daily low-dose aspirin did not have significantly lower rates of preterm birth than those who did not...

PFO Closure Reduces Migraine: New Meta-Analysis

A meta-analysis of two randomized studies evaluating patent foramen ovale (PFO) closure as a treatment strategy for migraine has shown significant benefits in several key...

Which Patients With Kidney Cancer Are Likely to Respond to ICI?

Several factors associated with a diminished response to immune checkpoint inhibitor (ICI) drugs among patients with metastatic clear cell renal cell carcinoma (ccRCC) have been...

Obesity ‘Clearly’ Not Tied to Worse Survival in MBC

The relationship between obesity and overweight and breast cancer has some elements of mystery. But this is not one of them: in metastatic breast cancer...

No Evidence That SNRIs Relieve Back Pain

While some guidelines support serotonin norepinephrine reuptake inhibitors (SNRIs) as treatments for back pain, a new systematic review and meta-analysis of existing research found no...

Labor Induction at 41 Weeks Tied to Lower Morbidity, Mortality Than Expectant Management

(Reuters Health) – Inducing labor at 41 weeks may result in a lower risk of severe adverse perinatal and neonatal outcomes than expectant management until...

JAMA Network Open Retracts Its First Paper, on Heart Disease

The authors of a 2019 meta-analysis in a JAMA journal on exercise and heart disease have retracted the paper after discovering that a quarter of the studies...

Sickle-Cell Trait May Not Independently Elevate CHD Risk

African Americans with sickle-cell trait (SCT), that is, who are heterozygous for the sickle-cell gene variant, don’t as a result necessarily have an elevated risk...

Chili Pepper Consumption Linked to Better Midlife Survival

In a meta-analysis of four geographically diverse observational studies, a higher intake of any type of chili pepper was associated with a lower rate of...

New ‘Wake-up’ Stroke Analysis Strengthens Case for Thrombolysis

Evidence supporting the use of thrombolysis for selected stroke patients with unknown time of onset has been strengthened with data from a new individual patient...