Tag: malignant skin neoplasm

When Is MRI Useful in Managing of Congenital Melanocytic Nevi?

When used for appropriate patients, MRI imaging is helpful in congenital melanocytic nevus (CMN) management and may help predict neurologic outcomes or drive neurosurgical intervention,...

Recent Trend: Melanoma Mortality Declining Rapidly

Declining trends in melanoma death rates accelerated from 2014 to 2018 in the United States, even as incidence rates increased for both males and females, according...

Latest FDA Pembrolizumab Approval Expands Label to Cutaneous SCCs

The Food and Drug Administration has approved pembrolizumab (Keytruda) monotherapy for locally advanced cutaneous squamous cell carcinoma (cSCC) that can’t be cured by surgery or...

Indoor Tanning ICD-10 Codes May Be Underused

Evaluation of a large insurance claims database has provided some insight into how ICD-10 indoor tanning codes are being used in practice, according to a...

EC Approves Cemiplimab for Advanced or Metastatic BCC

The European Commission (EC) has approved cemiplimab (Libtayo) for the treatment of adults with locally advanced or metastatic basal cell carcinoma (BCC) who progressed on —...

Many Sunscreens Have a Carcinogen, Pharmacy Tells FDA

Summer is around the corner, and with the pandemic waning for many, the CDC encourages people to spend more time unmasked outdoors. But protecting yourself...

Many Mohs Surgeons Are Struggling on the Job

Many Mohs surgeons are struggling on the job, and women seem to be especially vulnerable, a new survey suggests. In a measurement of well-being, 40%...

AAD Unveils New Guidelines for Actinic Keratosis Management

New guidelines from the American Academy of Dermatology strongly recommend the use of either 5-fluorouracil (5-FU) or imiquimod for the field treatment of actinic keratosis...

Ellie Guardino, MD, Battled Others’ Cancer, Has Died of Her Own

The oncology community is mourning the loss of Ellie Guardino, MD, PhD, a compassionate physician-scientist who fought through her own diagnosis of metastatic melanoma while...

Mohs Surgeons Favor Nicotinamide for Chemoprevention in Survey

Approximately three-quarters of Mohs surgeons recommended nicotinamide for prevention of keratinocyte carcinoma, in a survey of members of the American College of Mohs Surgeons. Although...

Made-to-Order TILs Effective Against Metastatic Melanoma

In just over one third of patients with metastatic melanoma who had experienced disease progression while receiving multiple prior lines of therapy, including immunotherapy and...

Chronic Immune-Related Adverse Events Likely Common After Anti-PD-1 Therapy for Melanoma

NEW YORK (Reuters Health) – Chronic immune-related adverse events (irAEs) associated with anti-programmed cell death-1 (PD-1) therapy for melanoma were more common than previously thought...

FDA Approves Cemiplimab-rwlc for NSCLC With PD-L1 Expression

The US Food and Drug Administration (FDA) has approved cemiplimab-rwlc (Libtayo) for the treatment of advanced non–small cell lung cancer (NSCLC). Specifically, the indication is...

Fecal Transplant Overcomes Resistance to Immunotherapy

For some patients with advanced melanoma whose conditions had stopped responding to immunotherapy, response was restored after treatment with fecal transplants. The material for the...

Entinostat Doesn’t Overcome Endocrine Resistance in Breast Cancer

The histone deacetylase (HDAC) inhibitor entinostat failed to overcome resistance to endocrine therapy in hormone receptor–positive, HER2-negative, advanced breast cancer in a phase 3 trial....

ICI for Cancer Ups Cardiac Event Risk: Danish Data

Immune checkpoint inhibitors (ICIs) increase the risk of cardiac events, including fatal heart attack and stroke, in patients with cancer, an analysis of Danish national...

Beta-Blocker May Improve Melanoma Treatment Response

Response rates were high without dose-limiting toxicities in a small phase 1 study that evaluated the addition of propranolol to pembrolizumab in treatment-naive patients with...

Mitotic Rate Makes Comeback as Melanoma Prognosticator

Mitotic rate, properly applied, has a prognostic impact in melanoma comparable to that of lesional ulceration, Mohammed Kashani-Sabet, MD, reported at a virtual forum on...

Real-World Results With Checkpoint Inhibitors Inferior to CT Data

Real-world survival outcomes for cancer patients on immune checkpoint inhibitors (ICIs) are inferior to outcomes reported in patients on clinical trials of ICIs, according to research...

New Technologies Show Promise for Treating Pigmented Lesions

Picosecond and nanosecond lasers are far more effective for treating individual lentigines, compared with other types of devices, but ultrashort pulses carry a higher risk...

Don’t Discount Ultrapotent Topical Corticosteroids for Vulvar Lichen Sclerosus

Ultrapotent topical corticosteroids remain the core treatment for vulvar lichen sclerosus, although other therapies can be added, according to an expert speaking at the virtual...

High TMB Predicts Response to Pembrolizumab

Tissue tumor mutation burden (tTMB) has been under study for some time as a biomarker that could predict which patients are most likely to respond...

Vitamin D Tied to Lower Risk for Immunotherapy-Induced Colitis

Taking vitamin D before starting immune checkpoint inhibitor (ICI) therapy may decrease the risk for treatment-related colitis, say researchers in an article published online on...

Nivolumab for Tough Tumor, End-of-Life Wording

Here are the most important stories that Medscape Oncology’s editors picked for you to read today: Nivolumab for a Rare, Aggressive Tumor Neoadjuvant nivolumab (Opdivo, Bristol-Myers...

Neoadjuvant Nivolumab ‘Promising’ in Merkel Cell Carcinoma

Neoadjuvant nivolumab (Opdivo, Bristol-Myers Squibb) could improve outcomes for patients with high-risk resectable Merkel cell carcinoma (MCC), say researchers reporting the first trial in this...