Tag: lipid lowering drugs

‘Quadpill’ Bests Monotherapy for Initial BP Lowering: QUARTET

A “quadpill” containing quarter doses of four blood pressure (BP)-lowering medications was more effective than monotherapy for initial treatment of hypertension, with similar tolerability, in...

CTA May Guide Primary Prevention Statins in Nonobstructive CAD

The relative risk of death or myocardial infarction (MI) went down with statin therapy in a cohort study of patients with either nonobstructive coronary artery...

No Overall Statin Effect Seen on Dementia, Cognition

Statin therapy likely didn’t lead to dementia or even mild cognitive impairment (MCI) in older patients taking the drugs for cardiovascular (CV) primary prevention in...

Real-world PCSK9i Data in FH Reveal Conundrum of Reimbursement

Patients with familial hypercholesterolemia (FH), particularly those with heterozygous FH, see their low-density-lipoprotein (LDL) cholesterol levels slashed with evolocumab (Repatha) and maintained out to 2...

Statins Beneficial in Elderly, Guidelines Should Be Strengthened

Contrary to historical evidence, among older people, elevated LDL cholesterol levels increase risk for heart attack and cardiovascular disease, and older patients benefit as much,...

SAMSON Pins Most Muscle Pain With Statins on the Nocebo Effect

A novel randomized trial taking on a vexing issue around one of the world’s most commonly prescribed medications has concluded that frequently intolerable statin side...

Data Contradict on Statin Effect in Diabetes With COVID-19

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Two observational studies have yielded opposite findings regarding the effect of...

Statins Linked to Lower Mortality Risk From Sepsis

Among individuals admitted to hospitals with sepsis, statin users had a lower mortality, compared with nonstatin users, according to a recent analysis focused on a...

Steep, Sustained Lipid Reductions Over Statins With LIB003

The novel anti-PCSK9 compound LIB003 substantially reduces low-density lipoprotein (LDL) cholesterol levels over 52 weeks in patients already taking maximally tolerated statins, results of an...

Evolocumab Safe and Effective in Pediatric FH

The PCSK9 monoclonal antibody evolocumab (Repatha, Repatha Repatha Amgen) was well tolerated and effectively lowered LDL cholesterol by 38% compared with placebo in a randomized controlled...

Statins Linked to Reduced Mortality in COVID-19

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Treatment with statins was associated with a reduced risk of a...

Icosapent Ethyl Cuts Revascularization: Latest From REDUCE-IT

A new analysis from the REDUCE-IT trial has shown that the high-strength eicosapentaenoic acid product icosapent ethyl (Vascepa, Amarin) reduced the number of revascularization procedures...

Statins and ICH: New Meta-Analysis

A new meta-analysis has concluded that the benefit of statin therapy in the prevention of ischemic stroke “greatly exceeds” the risk for intracerebral hemorrhage (ICH)....