Tag: genomic medicine

Low Plasma Transthyretin Linked to Risk of Heart Failure

Low plasma transthyretin, also known as prealbumin, is associated with incident heart failure in the general population, new research suggests. In two prospective, population-based studies...

FDA Clears First Drug for Rare Genetic Causes of Severe Obesity

The US Food and Drug Administration (FDA) has approved setmelanotide (Imcivree, Rhythm Pharmaceuticals) for weight management in adults and children as young as 6 years...

New Risks of Prescription Opioids Discovered

Prescription opioid use increases the risk for major depressive disorder (MDD) and anxiety and stress-related disorders (ASRD), new genetic evidence shows. The findings also suggest...

Triple Combination Benefits CF Patients With Advanced Disease

New CFTR [cystic fibrosis transmembrane conductance regulator] modulator therapies can offer life-altering benefits to some patients with cystic fibrosis, even those with advanced disease. Triple...

Trump No Longer Infectious, His Doctor Says

President Donald Trump is “no longer considered a transmission risk to others” for the coronavirus, according to a memo from his doctor released on Saturday...

CDER Chief Reflects on Advances in Rare Diseases

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Dr Janet Woodcock Since joining the Food and Drug Administration in...

New Drug for Prostate Cancer: Ipatasertib, an AKT Inhibitor

The investigational kinase inhibitor ipatasertib (Roche), which targets a key cancer metabolic pathway, has shown promise when used in combination with abiraterone (Zytiga) in the...

The Earlier the Better for Colchicine Post-MI: COLCOT

The earlier the anti-inflammatory drug colchicine is initiated after a myocardial infarction (MI) the greater the benefit, a new COLCOT analysis suggests. The parent trial...

The Role of Structural Racism in Delayed Autism Diagnoses

An analysis of a large cohort of African American children with autism spectrum disorder (ASD) reveals a more than 3-year time lag between parental recognition...

EXPLORER Hints at Potential New Drug Option in Obstructive HCM

An investigational drug that targets part of the molecular machinery underlying obstructive hypertrophic cardiomyopathy (HCM) can improve both symptoms and functional status in patients with...

Aggression Influenced by Genetic, Environmental Factors

Aggression in individuals is influenced by genetic and environmental factors, but can be reduced with treatment, according to Emil F. Coccaro, MD. “It actually is...

Gene Therapy Shows Good Results in BCG-Unresponsive NMIBC

More than half the patients with high-grade bacillus Calmette-Guérin (BCG)-unresponsive nonmuscle invasive bladder cancer (NMIBC) treated with nadofaragene firadenovec (Instiladrin), an investigational intravesical viral gene...

Genetic Differences by Ancestry and Prostate Cancer Therapies

There are genetic differences when comparing prostate tumors from African American men and European-American men, but none of these differences are of clinical significance for...

‘Worldwide Prevalence’ of OCD Higher in Women vs Men

Women have a higher lifetime risk than men for obsessive-compulsive disorder (OCD), a new meta-analysis suggests. Investigators analyzed 34 studies from around the world and...

Physicians, Patients Need to Know Limits of DNA Privacy Law

Because of the role genetic testing now plays in the management of cancer, and in the identification of risk for the disease, physicians should make...

Genetic Factors May Explain Divergent Outcomes in Severe TBI

A variation of the gene that encodes the B-cell lymphoma 2 (Bcl-2) protein increases the risk for intracranial pressure (ICP), cerebral edema, and need for...

Genetic Variant Might Contribute to Racial Disparity in COVID-19 Cardiac Mortality

NEW YORK (Reuters Health) — A genetic variant that increases the risk of drug-induced long QT syndrome (LQTS) and sudden cardiac death (SCD) could contribute to...

Genetic Test Identifies Ultra-High-Risk Myeloma Patients

A new test can identify patients with multiple myeloma (MM) who have a high-risk genetic profile as well as multiple chromosomal abnormalities. In this subgroup...