Tag: genomic medicine

Maternal Chronic Conditions Predict Cerebral Palsy in Offspring

Several maternal chronic conditions increase the risk of giving birth to a child with cerebral palsy, based on data from more than 1.3 million Norwegian...

US Boosts Virus Sequencing Efforts as More Variants Emerge

Nearly $200 million is being added to the Centers for Disease Control and Prevention (CDC) COVID-19 tracking efforts to find new strains of the virus. The...

FDA OKs First ‘Targeted Treatment’ for Rare DMD Mutation

The US Food and Drug Administration (FDA) has approved the antisense oligonucleotide casimersen (Amondys 45, Sarepta Therapeutics) injection for the treatment of patients with Duchenne...

Dissecting the CRISPR-baby stories | MIT Technology Review

After the 2017 meeting, He started reading biographies of scientific risk-takers who were ultimately hailed as heroes, from Edward Jenner, creator of the first vaccine,...

Variants Spur New FDA Guidance on COVID Vaccines, Tests, Drugs

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s  Coronavirus Resource Center. The US Food and Drug Administration (FDA) on Monday updated its...

Data ‘Favorable’ That Vaccines Limit Transmission

Researchers know by now the available COVID-19 vaccines prevent people from getting COVID around 95% of the time. But the million-dollar question remains: Are people...

COVID-19 Bill Would Scale Up Ability to Spot Virus Mutations

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. WASHINGTON (AP) — U.S. scientists would gain vastly expanded capabilities to...

Liquid vs Tissue Biopsy in Prostate Cancer: Why Not Both?

The genomic landscape of circulating tumor DNA (ctDNA) was comparable to the landscape of tissue biopsies in a large study of patients with metastatic castration-resistant...

Amivantamab Shows Promise in Challenging EGFR-Mutated NSCLC

A novel drug, the immune cell-directing antibody amivantamab (under development by Janssen), has shown promise for the treatment of patients with non–small cell lung cancer...

Genetic Deletions Drive SARS-CoV-2 Antibody ‘Escape’

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Recurrent genetic deletions in the SARS-CoV-2 spike protein can change the...

Common Genetic Disorder Tied to Increased Dementia Risk in Men

Men with iron overload due to hereditary hemochromatosis are at increased risk of developing dementia, an analysis of UK Biobank data indicates. Results of a...

UK Variant Spreading in the US as COVID Mutations Raise Stakes

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. The United Kingdom’s B117 variant is circulating in at least 24...

The Changing Brain Signature of HIV

Combination antiretroviral therapy (cART) has shifted HIV infection from a fatal to a chronic condition. New evidence now suggests this has been accompanied by a...

Triplet Shows ‘Promising’ Activity in Unresectable/Metastatic CRC

Combining an EGFR inhibitor with a pair of checkpoint inhibitors can produce “promising” activity in certain patients with colorectal cancer (CRC), according to an investigator...

California Urges Stop to 300K COVID-19 Vaccines After Some Fall Ill

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. LOS ANGELES (AP) — California’s state epidemiologist is urging a halt...

Gut Microbiome Predicts Nivolumab Efficacy in Gastric Cancer?

Preliminary data suggest that a certain pattern of gut microbes may be useful in predicting which patients with advanced gastric cancer are likely to benefit...

Lithium Resistance in Bipolar Tied to Deficient Gene Expression

A decrease in activation of a specific gene may explain why many patients with bipolar disorder (BD) do not respond to lithium, new research suggests....

Differences in Right vs Left Colon in Black vs White Individuals

The right colon appears to age faster in Black people than in White people, perhaps explaining the higher prevalence of right-side colon cancer among Black...

Wisconsin Pharmacist Thought Vaccine Was Unsafe

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. MADISON, Wis. (AP) — A Wisconsin pharmacist convinced the world was...

Lp(a) and LPA Gene Score ‘Modest’ Predictors of CVD Risk

Although lipoprotein(a) (Lpa) levels and LPA genetic risk scores are both significantly associated with atherosclerotic cardiovascular disease (ASCVD) events, they appear to offer only a...

Virus ‘Endemic,’ Expect More Variants, Vaccine Tweaks

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. After a new, potentially more easily transmissible genetic variant of SARS-CoV-2...

Vaccine Rollout On Track, Expect 300M Doses Through March

Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. If the initial success of the Pfizer-BioNTech rollout continues, and emergency use authorization (EAU)...

Charting of the Human Genome, 20 Years Later

Twenty years ago, President Bill Clinton announced completion of what was arguably one of the greatest advances of the modern era: the first draft sequence...

Low Plasma Transthyretin Linked to Risk of Heart Failure

Low plasma transthyretin, also known as prealbumin, is associated with incident heart failure in the general population, new research suggests. In two prospective, population-based studies...

FDA Clears First Drug for Rare Genetic Causes of Severe Obesity

The US Food and Drug Administration (FDA) has approved setmelanotide (Imcivree, Rhythm Pharmaceuticals) for weight management in adults and children as young as 6 years...