Tag: clinical research

Cryptococcal Meningitis: Single-Dose Regimen Noninferior

A single high dose of the antifungal agent liposomal amphotericin B (L-AmB; AmBisome, Gilead Sciences), with a background regimen of flucytosine and fluconazole, is noninferior...

Failed viral suppression in CAB/RPV linked to 3 Risk Factors

A body mass index (BMI) ≥30 kg/m2, rilpivirine resistance–associated mutations, and the HIV-1 subtype A6/A1 can raise a person’s risk for confirmed virologic failure (CVF)...

Meet the Patients Who Helped Run a Big Aspirin Trial

When Tom McCormick got an unexpected call from his doctor, the first thing his doctor said was, “I’m not calling you about anything about your...

The Robot Comes to Mastectomy, But Cancer Outcomes Data Not Attached

Clinical trials underway across the US are exploring the use of robotic surgical devices for nipple-sparing mastectomy, but are either not collecting cancer outcomes or...

Vaccine Breakthrough Cases Rising With Delta: Here’s What That Means

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. At a recent town hall meeting in Cincinnati, Ohio, President Joe...

Dolutegravir Confirmed as Effective Second-Line HIV Therapy

Dolutegravir and ritonavir-boosted darunavir are equally effective second-line treatments for HIV-1, even for patients with resistance to nucleoside reverse-transcriptase inhibitors (NRTIs) in the regimen, a...

Pfizer, AZ Vaccines Effective Against Delta, After 2 Doses: Study

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. The Pfizer-BioNTech and AstraZeneca vaccines — the primary vaccine options in...

New Treatment Option for Restless Legs?

The antiplatelet medication dipyridamole reduces motor and sensory symptoms of restless legs syndrome (RLS) and improves sleep duration for treatment-naive patients, results of a small, randomized,...

Adjustments to BPaL Regimen Reduce AEs, Not Efficacy

Lower doses of linezolid in the BPaL drug regimen (bedaquiline, pretomanid, and linezolid) significantly reduce the adverse events associated with the treatment for patients with highly...

AHS Releases Updated Guidance on New Migraine Treatments

An updated consensus statement from the American Headache Society (AHS) offers detailed recommendations on the use of novel acute and preventive treatments in adult patients...

Protein Expression May Predict HBV DNA Suppression

Stopping nucleoside analog therapy in patients with hepatitis B viral (HBV) infections results in sustained viral suppression in only a minority of patients, but a...

IV Iron Can Save Costs in HF With Iron Deficiency in Analysis

Intravenous iron therapy was predicted to be highly cost-effective or even cost-saving when used in high-risk, iron-deficient patients with heart failure (HF) in each of...

Rupture Risk Calculator Guides Management

An autograft risk calculator based on patient traits accurately predicted the odds of graft rupture in young, active individuals who underwent anterior cruciate ligament reconstructions...

Drug Effective in Treating Symptoms of Postpartum Depression

Those suffering from postpartum depression may have a more convenient treatment option, compared with the only drug approved by the Food and Drug Administration to...

Lottery Incentives Don’t Increase COVID-19 Vaccination Rates

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Lottery-based incentives such as cash and prizes don’t appear to increase...

Diet Rich in Omega-3s Linked to Fewer Migraines, Less Pain

A diet rich in omega-3 fatty acids reduces the frequency and intensity of monthly migraine attacks, a new study suggests. In this interventional study, a...

Novel Oral Inhibitor May Block Intestinal Damage

A novel oral inhibitor of transglutaminase 2 appears to block gluten-induced mucosal damage in patients with celiac disease at three different doses, based on proof-of-concept...

Walking Speed Following Stroke a Good Predictor of Recovery?

Walking speed after stroke may help predict which patients will show greater post-rehab improvement in their ability to simultaneously walk and perform a second task,...

Heartburn Drugs Improve Blood Sugar Control in Diabetes

WASHINGTON—Antacids improved blood sugar control in people with diabetes but had no effect on reducing the risk of diabetes in the general population, according to...

Probiotic Supplementation Regulates Newborn Immune System

Supplementing breastfed infants with bifidobacteria promotes development of a well-regulated immune system, theoretically reducing risk of immune-mediated conditions like allergies and asthma, according to investigators....

Topical Ruxolitinib Found Safe, Effective in 52-Week AD Study

After treatment with ruxolitinib cream for 52 weeks, between 60% and 80% of atopic dermatitis patients maintained clear or almost clear skin, with no safety...

Key Driver of Fish Oil’s Antidepressant Effects Revealed

A key molecular mechanism underpinning the anti-inflammatory, antidepressant, and neuroprotective effects of omega-3 fatty acids has been identified.   In findings that could lead to...

Inexpensive Dye Tracks Digestive Transit Time

When it comes to measuring gut transit time, blue dye could be a cost-effective and simple alternative to other, more burdensome methods. The approach, which...

Emerging Schizophrenia Drugs Target Negative Symptoms

Late-stage trials of new antipsychotic drugs are showing promise in the control of negative symptoms, according to an overview presented by Current Psychiatry and the...

Moderna Seeks FDA OK for Adolescent COVID Vaccine

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center. Moderna has filed for emergency use authorization from the U.S. Food...