Home > Health > BinaxNOW rapid antigen test has lower sensitivity than RT-PCR

BinaxNOW rapid antigen test has lower sensitivity than RT-PCR

44 Views

The Abbott BinaxNOW COVID-19 Ag Card (BinaxNOW) rapid antigen test has lower sensitivity than reverse transcription-polymerase chain reaction (RT-PCR) for detecting severe acute respiratory syndrome coronavirus 2 infection, according to research published in the Jan. 19 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

Jessica L. Prince-Guerra, Ph.D., from the CDC COVID-19 Response Team, and colleagues examined the performance of the BinaxNOW rapid antigen test. BinaxNOW was used with real-time RT-PCR testing for the analysis of 3,419 paired specimens collected from persons aged 10 years and older during Nov. 3 to 17, 2020, in Pima County, Arizona. Viral culture was performed on 274 of 303 residual real-time RT-PCR specimens positive by either test.

The researchers found that the BinaxNOW antigen test had a sensitivity of 64.2 and 35.8 percent for specimens from symptomatic and asymptomatic persons, respectively, with near 100 percent specificity in specimens from both groups. Virus was cultured from 35 percent of the specimens, including 57.8 percent of 147 specimens with concordant antigen and real-time RT-PCR positive results and 8.9 percent of 124 and none of three with false-negative and false-positive antigen test results, respectively.

“Despite their reduced sensitivity to detect infection compared with real-time RT-PCR, antigen tests might be particularly useful when real-time RT-PCR tests are not readily available or have prolonged turnaround times,” the authors write.


Follow the latest news on the coronavirus (COVID-19) outbreak


More information:
Abstract/Full Text

Copyright © 2020 HealthDay. All rights reserved.

Citation:
BinaxNOW rapid antigen test has lower sensitivity than RT-PCR (2021, January 21)
retrieved 21 January 2021
from https://medicalxpress.com/news/2021-01-binaxnow-rapid-antigen-sensitivity-rt-pcr.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

Source link

TAGS
Hi guys, this is Kimmy, I started LicensetoBlog to help you with the latest updated news about the world with daily updates from all leading news sources. Beside, I love to write about several niches like health, business, finance, travel, automation, parenting and about other useful topics to keep you find the the original information on any particular topic. Hope you will find LicensetoBlog helpful in various ways. Keep blogging and help us grow as a community for internet lovers.